Approximate effective sample size from GWAS of related samples (copied from flashfm)

Approximate effective sample size from GWAS of related samples (copied from flashfm)

Neff(raf, seB, Vy = 1)

Arguments

raf

vector of reference (or minor) allele frequencies for all SNPs in the GWAS

seB

vector of standard errors of SNP effect estimates, in same order as SNPs in raf

Vy

trait variance; default is 1 under assumption trait is transformed to a standard Normal distribution

Value

Estimate of effective sample size

Author

Jenn Asimit