Calculate kappa for a given region and priors on the number of causal variants in the region, and the prior odds of causal variant sharing
calckappa(nsnps, p, ndis, target.odds)
| nsnps | number of snps in the region |
|---|---|
| p | probability any snp is causal (assumes a binomial distribution for the number of causal snps, with expected number = p * nsnps) |
| ndis | number of diseases |
| target.odds | prior odds of NO SHARING of causal variants between a single trait and any of the other trait. ie a value < 1 indicates a prior expectation that no sharing is less likely than sharing. |
the value of kappa corresponding to supplied target.odds