Approximate (fast) marginal PP for models of a set of diseases, sharing information between the diseases

PPmarginal.multiple.fast.fn(SM2, dis, thr, kappa, fthr, N0, ND, nsnps)

Arguments

SM2

List of snpmod objects for a set of diseases

dis

Vector of diseases for fine-mapping (subset from those in SM2)

thr

Threshold such that the smallest set of models has cumulative PP >= thr

kappa

Vector of sharing values

fthr

Second level filtering on all but first disease to give a faster approximation; retain SNPs within the smallest set of models such that cumulative PP >= thr

N0

number of shared controls

ND

list of number of cases for a set of diseases

nsnps

Number of SNPs in region

Value

List consisting of PP: marginal PP for models and MPP: marginal PP of SNP inclusion